Prognostic value of hedgehog signal component expressions in hepatoblastoma patients

Prognostic value of hedgehog signal component expressions in hepatoblastoma patients

OBJECTIVE Activation of hedgehog (Hh) pathway has been implicated in the development of human malignancies. Hh as well as related downstream target genes has been extensively studied in many kinds of malignant tumours for clinical diagnostic or prognostic utilities. This study aimed at investigating whether Hh molecules provides a molecular marker of hepatoblastoma malignancy. METHODS We obta...

Prognostic value of sonic hedgehog protein expression in gastric cancer.

OBJECTIVE Sonic hedgehog is produced in gastric epithelial cells and plays a crucial role in parietal cell function and the regulation of gastric epithelial cell differentiation. Emerging evidence suggests that the sonic hedgehog pathway is not only involved in the development of cancers but also in their progression and aggressiveness. METHODS To assess its prognostic value in gastric cancer...

Prognostic value of right ventricular myocardial performance index in patients undergoing coronary artery bypass surgery

 Abstract Background: Right ventricular myocardial performance index (RVMPI) is a Doppler–derived parameter of non-geometrical ventricular function that measures both systolic and diastolic functions of the right ventricle. The aim of this study is to compare prognostic value of RVMPI with global RV function in patients undergoing Coronary Artery Bypass Graft (CABG). Methods: In a longitudinal ...

The Prognostic Value of Admission Glasgow Coma Scale and AVPU in Acute Drug Poisoning Patients

Clinical prognostic value of DNA methylation in hepatoblastoma: Four novel tumor suppressor candidates

Hepatoblastoma (HB) is very rare but the most common malignant neoplasm of the liver occurring in children. Despite improvements in therapy, outcomes for patients with advanced HB that is refractory to standard preoperative chemotherapy remain unsatisfactory. To improve the survival rate among this group, identification of novel prognostic markers and therapeutic targets is needed. We have prev...